Florence is located at the intersections of interstates 20 and 95. Interstate 20 extends from Texas and ends in Florence, where it merges with Interstate 95 – providing direct highway access to New York City and Miami, Florida.

Traveling to Florence from the following metro areas by vehicle will require long drives, breaks and stops along the way:

- Dallas-Fort Worth: 16 hours (2 days roundtrip)

Recommended mid-point hotel resting destination while traveling -Meridian, Mississippi or Tuscaloosa, Alabama

- New York City:10 hours

- Washington, D.C./Northern Virginia/Baltimore: 8 hours

- Atlanta: 6 hours

- Richmond/Hampton Roads: 4.5 hours

- Winston-Salem/Greensboro: 3 hours

- Charlotte: 1.5 hours

- Myrtle Beach: 1.5 hours

- Columbia: 1.5 hours

Metro Florence is served by Florence Regional Airport (FLO) in Florence, South Carolina. The airport is only served by United Airways through a connection at Charlotte Douglas International Airport (CLT) in Charlotte, North Carolina, with direct daily morning, afternoon and one evening flight into Florence.

NOTE: Direct flights into FLO can be costly. However, the convenience for some travelers makes up for the cost. Enterprise and Avis car rental services are available at FLO.

Myrtle Beach International Airport (MYR) and Columbia Metropolitan Airport (CAE) are 75 miles and 85 miles, respectively, away, and will require you to purchase a rental vehicle to reach Florence, as neither airport provides connections to FLO.

Amtrak runs daily service via the Palmetto and Silver Meteor lines to Florence (FLO), starting in New York City and ending in Miami, Florida. Local taxis, Uber and Lyft rides are available from the Florence Amtrak Station at 805 E. Day St. behind the McLeod Regional Medical Center complex in downtown Florence..