Driving

Florence is conveniently located at the intersection of Interstates 20 and 95. Interstate 20 extends from Texas and terminates in Florence, where it merges with Interstate 95, providing direct highway access to destinations along the East Coast, including New York City and Miami, Florida.

Traveling to Florence by car from the following metropolitan areas may require extended driving time, along with planned rest stops and overnight breaks:

• Dallas–Fort Worth: Approximately 16 hours
  Recommended midpoint overnight stops: Meridian, Mississippi, or Tuscaloosa, Alabama

• New York City: Approximately 10 hours

• Washington, D.C./Northern Virginia/Baltimore: Approximately 8 hours

• Atlanta: Approximately 6 hours

• Richmond/Hampton Roads: Approximately 4.5 hours

• Winston-Salem/Greensboro: Approximately 3 hours

• Charlotte: Approximately 1.5 hours

• Myrtle Beach: Approximately 1.5 hours

• Columbia: Approximately 1.5 hours

Flying to Florence, South Carolina

Florence is served by Florence Regional Airport (FLO), located in Florence, South Carolina. FLO is currently serviced by United Airlines, with flights connecting through Charlotte Douglas International Airport (CLT) in Charlotte, North Carolina. Travelers can choose from daily morning, afternoon, and evening arrivals into Florence.

While direct flights into FLO may be higher in cost, many travelers find the convenience well worth it. Enterprise and Avis rental car services are available on site for ground transportation.

Additional airport options include Myrtle Beach International Airport (MYR) and Columbia Metropolitan Airport (CAE), located approximately 75 miles and 85 miles from Florence, respectively. Travelers flying into these airports will need to arrange rental transportation to Florence, as neither offers connecting service to FLO.

Railway:

Amtrak provides daily service to Florence via the Palmetto and Silver Meteor lines, with routes running from New York City to Miami, Florida. The Florence Amtrak Station, located at 805 E. Day Street behind the McLeod Regional Medical Center complex in downtown Florence, offers convenient access to local transportation.

Taxis, as well as Uber and Lyft, are readily available from the station for travel throughout the Florence area.